鸦胆子油乳联合替莫唑胺治疗恶性胶质瘤研究

Brucea oil emulsion combined with temozolomide for the treatment of malignant gliomas

目的探讨鸦胆子油乳联合替莫唑胺治疗恶性胶质瘤患者的临床疗效。方法选取我院104例胶质瘤患者,依据入院先后顺序分为试验组和对照组,每组52例。试验组应用鸦胆子油乳注射液联合替莫唑胺,对照组单纯应用替莫唑胺。两组均以28 d为1个化疗周期,均完成6个化疗周期,观察临床疗效、未进展存活率评定、毒副反应和生存质量评分变化。结果两组临床疗效相比试验组总有效率为55.7%,对照组总有效率为22.6%,试验组优于对照组,差异有统计学意义(P<0.05);两组未进展存活率评定发现试验组第3、6个化疗周期后均高于对照组(P<0.05)。试验组生活质量改善率为75%,对照组为34.6%,试验组明显高于对照组,差异有统计学意义(P<0.05)。试验组白细胞计数减少发生率为26.9%,对照组为28.8%,差异无统计学意义(P>0.05)。结论鸦胆子油乳注射液联合替莫唑胺治疗胶质瘤能提高疗效及改善胶质瘤患者的生活质量。

Objective The clinical efficacy of Brucea oil emulsion combined with temozolomide in treatment the patients with malignant glioma was studied.MethodsA total of 104 cases of glioma patients were divided into experimental and control groups according to the time of admission. All the cases in experimental group were performed Brucea oil emulsion injection and temozolomide, while the cases in control group applied only temozolomide. In both two groups, 28 days were set as a chemotherapy cycle and all the cases completed six chemotherapy cycles. The changes of clinical efficacy, progressioning free survival, toxicity and quality of life score were observed.ResultsThe total effective rate was 55.7% in the experimental group and 22.6% in the control group with significant difference （P〈0.05）. The progressiong free survival in experimental group was higher than that of control group after 3 and 6 cycles of chemotherapy （P〈0.05）. The quality of life was 75% in the experimental group and 34.6% in the control group, and the difference between these two groups was statistically significant （P〈0.05）. The white blood cell count decrease was 26.9% in the experiment group and 28.8% in control group. The difference was not statistically significant （P〉0.05）.ConclusionJavanica oil emulsion injection combined with temozolomide therapy can improve the efficacy of glioma and the quality of life in patients with glioma.