摘要
目的研究艾司唑仑对老年失眠患者吞咽功能的影响。方法将82例老年失眠患者按随机数字表法分为观察组(42例)和对照组(40例)。观察组每晚给予艾司唑仑1 mg,对照组则予安慰剂。在治疗前和治疗4周后分别对入组患者进行洼田饮水试验、进食评估问卷调查工具-10(EAT-10)量表和视频透视吞咽检查(VFSS)。结果治疗前后比较,观察组的洼田饮水试验评级和EAT-10量表评分均有显著提高,VFSS评分显著下降,差异均具有统计学意义(均P<0.05)。与对照组治疗4周后比较,观察组患者的洼田饮水试验评级和EAT-10量表评分也有显著升高,VFSS评分显著降低,组间差异均具有统计学意义(Ρ<0.05)。结论艾司唑仑可以加重老年失眠患者的吞咽障碍。
AIM To study the effects of estazolam on swallowing function in elderly insomnia patients. METH- ODS Totally 82 elderly insomnia patients were randomly divided into observation group（ 1 mg estazolam every night,4 weeks, n = 42） and control group（ placebo every night, 4 weeks, n = 40）. Kubota＇ s water drinking test, eating assess- ment questionnaire tool（EAT-10） and videofluoroscopy were used to assess the swallowing function of the patients before treatment and after 4 weeks of treatment. RESULTS After 4 weeks, the scores of Kubota＇s water drinking test and EAT- 10 of the observation group improved significantly than before treatment （P 〈 0.05）, and had improved significantly than control group（P 〈 0.05, P 〈 0.01）. CONCLUSION Estazolam can impair swallowing function in the elderly insomnia patients.
出处
《中国临床药学杂志》
CAS
2016年第5期267-270,共4页
Chinese Journal of Clinical Pharmacy
基金
2016年绍兴市卫生计生科技计划(编号2016CX009)
关键词
老年人
入睡和睡眠障碍
吞咽障碍
艾司唑仑
the elderly
sleep initiation and maintenance disorder
deglutition disorder
estazolam
