幽门螺旋杆菌感染对帕金森病的影响

Effect of Helicobacter Pylori on Parkinson's Disease

幽门螺旋杆菌是消化系统常见的致病菌,通常与消化性溃疡相关。然而,近来的研究显示幽门螺旋杆菌感染与很多疾病相关。虽然机制尚不明确,但研究指出幽门螺旋杆菌能抑制许多药物在胃肠道的吸收。研究发现,幽门螺旋杆菌感染在帕金森病(PD)患者中患病率较高,继而影响左旋多巴的吸收导致患者症状波动明显。对幽门螺旋杆菌感染的PD患者使用抗生素进行幽门螺旋杆菌根除治疗能增加左旋多巴的吸收,减少患者症状波动。

Helicobacter pylori（HP） is a common infection of the gastrointestinal system that is usually related to peptic ulcers. However, recent studies have revealed the relationships between HP and many other diseases. Although the exact mechanism is unknown, HP can prevent the absorption of certain drugs from the gastrointestinal tract. A high prevalence of HP has been found in patients with Parkinson＇s disease（PD）, and these bacterium cause motor fluctuations by affecting the absorption of levodopa. Eradicating HP from patients with PD by applying antibiotic treatment will increase the absorption of levodopa and decrease their motor fluctuations.