系统性红斑狼疮与妊娠

Systemic Lupus Erythematosus (SLE) and Pregnancy

系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种多器官、多系统受累,严重危害人类健康的自身免疫性疾病,好发于生育期女性。目前临床上治疗SLE主要包括糖皮质激素、免疫抑制剂及其他辅助药物等。妊娠阶段是女性生命过程中的一个特殊时期,SLE合并妊娠,特别是在SLE疾病活动期或存在肾脏损害的情况下,往往导致子痫前期、流产、早产、胎儿生长受限、足月小于胎龄儿和胎儿先天性心脏病等。因此,SLE患者妊娠被视为高危因素,需要在此期间密切的监视并确保孕期病情处于稳定状态。治疗SLE合并妊娠者需要兼顾母体和胎儿,对药物的安全性及治疗的有效性有较高的要求。

Systemic lupus erythematosus （SLE） is a severe autoimmune disease which causes multi-organ and muhi-system dysfunction. It mainly occurs in reproductive women. So far, treatments for SLE are glucocorticoid, immunosuppressor, and other symptomatic relief and supportive treatments. Pregnancy is considered as a special period in the process of female life. SLE pregnant women,especially with active SI,E disease or renal dysfunction,often leads to preeclampsia, abortion, premature delivery., intrauterine growth retardationand neonatal congenital heart disease. Therefore, SLE pregnant womenare considered as high risk factors,which need a close monitor and ensure the disease is stable during pregnancy. Safety and effective treatment are needed for SLE pregnant women.