绵萆薢化学成分的分离与结构鉴定

Isolation and structural identification of constituents from Dioscoreae spongiosae Rhizoma

[目的]对绵萆薢的化学成分进行研究。【方法】采用大孔吸附树脂、ODS、Sephadex LH-20等柱色谱及制备型高效液相色谱法对其所含化学成分进行分离、制备，并利用波谱学方法鉴定了结构。【结果】从绵萆薢提取物中分离鉴定了Tachioside（1）、Isotachioside（2）、3,5-二甲氧基熊果苷（3）、2,6-二甲氧基-4-羟基-苯酚-1-O-β-D-吡喃葡萄糖苷（4）、淫羊藿次苷D：（5）、苯甲醇-O-β-D-吡喃葡萄糖苷（6）和腺苷（7）等7个单体成分。【结论】化合物l～3为首次从薯萆薢中分离得到，4～7为首次从该植物中分离得到。

[Objective] Study on chemical constituents of Dioscoreae spongiosae Rhizoma. [Methods] The chemical constituents were obtained by ODS, Sephadex LH-20 and PHPLC ehromatorgraphy isolation, and identified by chemical and spectral analysis. [Results] The structures of seven eomounds were elucidated to be taehioside （1）, isotachioside （2）, koaburaside （3）, 2,6-dimethoxy-4-hydroxyphenol-l-O-β-D-glucopyranoside （4）, ieariside D2 （5）, benzyl alcohol O-β-D-glucopyranoside （6）, and adenosine （7）, respectively. [Conclusion] Compounds 1-3 were obtained from Dioscoreae genus firstly, and 4-7 was isolated from the plant for the first time.