四川省1例脊髓灰质炎疫苗高变异株病例的流行病学调查与分析

Epidemiological Investigation and Analysis of a Case Caused by Highly Variant Vaccine-Derived Poliovirus in Sichuan Province

目的阐述四川省1例脊髓灰质炎(脊灰)疫苗高变异株病例的流行病学调查与分析。方法按照相关要求,对疫情开展病例个案调查、实验室检测、病毒传播风险评估、应急处置等相关工作。结果 2014-06,四川省发现1例脊灰疫苗高变异株病例。事件发生后,四川省严格按照相关要求开展了多项应急处置措施,成功控制疫情,未再发现新发病例。结论通过本次事件的应对证明了《脊髓灰质炎野病毒输入性疫情和疫苗衍生病毒相关事件应急处置技术方案(试行)》的有效性和可操作性。同时,本次事件也暴露出了四川省在维持无脊灰工作中存在的一些漏洞和不足,需在今后的工作中不断完善和改进。

Objective To elaborate the epidemiological investigation and analysis of a case caused by highly vari- ant vaccine - derived poliovirus （VDPV） in Sichuan province. Methods Related work including case investiga- tion, laboratory test, assessment of virus transmission risks and emergency response was conducted following related requirements. Results In June 2014, a case caused by highly variant VDPV was found in Sichuan Province. Upon occurrence of the event, multiple emergency response measures were taken strictly following related requirements, successfully controlled the epidemic and preventing emergence of new cases. Conclusion Responses to sibility of the the event have verified effectiveness and lea Technical Protocol for Emergency Response to Importation of Wild Poliovirus and Vaccine - derived Virus Related Events （Interim）. The event also implies the imperfectness of Sichuan province in poliomyelitis control and indicates continual improvement is needed in the future.