2014年桂林市秀峰区1～29岁人群乙肝血清学调查分析

Aalysis of Serological Survey on Hepatitis B Ranged From 1 to 29 Years Old in Guilin City in 2014

目的了解桂林市2014年1~29岁人群HBs Ag流行率、HBV感染率及抗乙肝病毒表面抗原抗体（Antibody to HBs Ag,HBs Ab）水平,为评估＂十二·五＂乙肝防控目标完成情况提供参考数据,并为完善乙肝疫苗策略提供科学依据。方法对桂林市秀峰区2个乙型病毒性肝炎血清流行病学监测点共286人开展现场流行病学调查,并采集血样进行HBV血清学指标检测。结果 286份样本中,HBs Ag阳性0人,HBV感染阳性21人,阳性率为7.3%;HBs Ab阳性187人,阳性率为65.4%,不同年龄组阳性率差异有统计学意义（P〈0.01）。乙肝五项全阴人数78人,阴性率为27.3%,其中1~4岁年龄组阴性率为15%,5~14岁为40.2%,15~29岁为26.2%,各年龄组全阴率差异无统计学意义（P〉0.05）。结论桂林市1~29岁人群乙肝感染率处于较低的水平,感染者主要集中在15~29岁人群;HBs Ab阳性率不高,阳性者主要集中在1~4岁人群;1~4岁人群仍有相当一部分乙肝五项全阴者,对这部分免疫无应答或弱应答者应尽快进行重种。

Objective To analyze the HBsAg carrying rate and the level of HBsAb in different age groups in Guil- in, so as to provide evidence for the prevention and control of hepatitis B. Methods This information and ve- nous blood were collected from 2 investigational sites （with about 286 people） during the national hepatitis B serological study （Oct, 2014）. The samples were tested by the Center of Disease Control and Prevention. ELISA method was used in this serological study. Results 0 out of 286 samples （0%） were positive for HBsAg and 21 out of 286 samples were infected by Hepatitis virus B, the positive rate was 7.3%. 187 participants were positive （65.4%） in HBsAb. There was a variation in the positive rate of HBsAb in different ages （P 〈 0.01 ）. It shows no statistically significant differece in the of negetivity in different ages （P 〉 0. 05 ）. Conclusion The infection of Hepatitis virus B is at a low level in Guilin, mainly from the people ranged from 15 to 29 years old. HBsAb positive rate is not high, mainly from the people ranged from 1 to 4 years old. Serologial neg- ative children should be reimmunized.