胃癌组织中CXCR3表达与微血管形成的关系及其临床意义

Correlation of CXCR3 expression with angiogenesis and its significance in gastric cancer

目的探讨胃癌组织中CXCR3的表达和微血管形成的关系并分析其临床意义。方法采用免疫组化法检测169例胃癌组织中CXCR3蛋白表达和肿瘤间质微血管密度(microvascular density,MVD),分析其相关性及其与胃癌临床病理参数的关系。结果 CXCR3表达在分化程度高(P=0.025)、浸润程度浅(P=0.005)、TNM分期低(P=0.002)及无淋巴结转移(P=0.001)的胃癌患者中更高;MVD在胃癌分化程度低者中更高(P=0.001),与浸润深度、TNM分期及淋巴结转移无关(P>0.05)。胃癌组织中CXCR3表达与MVD呈负相关(r=-0.151,P=0.049)。Kaplan-Meier分析发现高表达CXCR3的胃癌患者(P=0.015)和低MVD患者(P=0.047)的生存时间延长。结论胃癌中CXCR3的表达与MVD呈负相关,且与胃癌的浸润、转移相关。

Purpose To explore the correlation between chemokine receptor CXCR3 expression with angiogenesis in gastric cancer （GC） and to analyze its significance. Methods The expression of CXCR3 in tumor cells and microvascular density （MVD） in tumor stroma were detected in 169 GC tissues by immunohistochemical （IHC） staining. The relationship between CXCR3 expression and MVD, and correlation with clinical pathological factors were analyzed. Result CXCR3 expression was inversely associated with dif- ferentiation （ P = 0. 025 ）, invasion （ P = 0. 005 ）, TNM stage （ P = 0. 002 ） and lymph nodes metastasis （ P = 0. 001 ）. MVD was high- er in poorly-differentiated GC tissues （P = 0. 001 ）, while not correlated with invasion, TNM stage and lymph nodes metastasis （all P 〉0. 05）. What＇ s more, the expression of CXCR3 was negative associated with MVD （r = -0. 151, P =0. 049）. Kaplan-Meier anal- ysis indicated that high expression of CXCR3 and low MVD were associated with improved overall survival （OS） （ Log-rank, P = 0. 015 and P = 0. 047, respectively）. Conclusion CXCR3 expression and MVD are negative correlation, and are associated with GC inva- sion and metastasis.