摘要
病毒本身和机体免疫应答是影响HBV感染病情进展和临床转归的重要因素。目前免疫学研究及临床观察结果表明,单纯的抗病毒治疗无法重建慢性乙型肝炎患者的抗病毒免疫功能,因而无法彻底治愈HBV感染。联合新的免疫治疗策略,根据疾病的不同阶段采取针对性的治疗方案,可能是实现HBV感染治愈的有效方法。本文综述慢性乙型肝炎治疗的现状与进展。
HBV itself and the host immune responses determine the outcome of HBV infection, which can be either acute or chronic. Current immunological researches and clinical observations have revealed that existing antiviral drugs cannot restore the antiviral immunity of patients with chronic hepatitis B, and therefore can not completely eliminate HBV. Combined with new immunotherapy, according to the different stages of disease to adopt individualized treatment, may be an effective way to achieve the cure of HBV infection. Here, the current progress and challenges of chronic HBV infection will be reviewed.
作者
史继静
常文仙
李元元
王福生
SHI Jijing CHANG Wenxian LI Yuanyuan WANG Fusheng(Department of Infectious Diseases, 302 Military Hospital of China-Peking University Teaching Hospital, Beijing 100039, China Bengbu Medical College, Bengbu 233000, China Department of Infectious Diseases, Beijing 302 Hospital, Beijing 100039, China)
出处
《科技导报》
CAS
CSCD
北大核心
2016年第20期34-39,共6页
Science & Technology Review
关键词
慢性乙型肝炎
疾病进展
抗病毒治疗
免疫治疗
chronic hepatitis B
disease progression
antiviral therapy
immunotherapy
