淮海地区汉族冠心病患者CYP2 C19基因多态性分析

An analysi on the genetic polymorphism of CYP2C19 in patients of the Han ethnic group with coronary heart disease in Huaihai area

目的：分析淮海地区汉族冠状动脉粥样硬化性心脏病（简称冠心病）患者CYP2C19基因多态性分布特征。方法提取DNA，PCR扩增后，芯片杂交法进行基因分型，结果以直接测序法验证。比较不同人群的基因频率，对926例淮海地区汉族冠心病患者CYP2C19基因多态性进行分析。结果 CYP2C19＊1／＊1、CYP2C19＊1／＊2、CYP2C19＊1／＊3、CYP2C19＊2／＊2、CYP2C19＊2／＊3和CYP2C19＊3／＊3基因型出现频率分别为41．47％、39．85％、6．05％、8．85％、3．35％和0．43％。结论淮海地区汉族冠心病患者与周边地区汉族冠心病患者的CYP2C19基因多态性分布相类似。

Objective To investigate the distribution of CYP2C19 polymorphism in patients of the Han ethnic group with coronary artery disease in Huaihai area.Methods A total of 926 patients carrying CYP2C19 from the Han ethnic group with coronary artery disease in Huaihai area.Their genetic polymorphism of CYP2C19 was detected by DNA mi-croarray.Results The genotype frequency was 41.47% for CYP2C19＊1/＊1, 39.85% for CYP2C19＊1/＊2, 6.05%for CYP2C19＊1/＊3, 8.85%for CYP2C19＊2/＊2, 3 .35%for CYP2C19＊2/＊3 and 0.43%for CYP2C19＊3/＊3.Conclusions Patients from the Han ethnic group with coronary artery disease in Huaihai area show the similar distribution of CYP2C19 genetic polymorphism with those from the Han ethnic group with coronary artery disease from oth-er surrounding area.