摘要
目的评定黄连Coptis chinensis Franch.中10种重金属元素含有量的不确定度。方法黄连粉碎后加硝酸和氢氟酸消解,电感耦合等离子体质谱(ICP-MS)法测定其中10种重金属元素的含有量,评定所得结果的不确定度。结果Cr、Mn、Co、Ni、Cu、As、Cd、Ba、Tl、Pb的不确定度分别为0.28、14、0.054、0.20、2.1、0.017、0.10、3.3、0.009 4、0.33 mg/kg,其质量浓度是不确定度的主要来源。结论黄连标准曲线绘制过程中应选择较大量程的移液器,并减少稀释步骤,以提高准确性。
AIM To evaluate the uncertainties of contents of ten heavy metal elements in Coptis chinensis Franch. METHODS After being grinded,C. chinensis was added with nitric acid and hydrofluoric acid for digestion. The contents of ten heavy metal elements were determined by inductively coupled plasma mass spectrometry（ ICP-MS）,then the uncertainties of obtained results were evaluated. RESULTS The uncertainties of Cr,Mn,Co,Ni,Cu,As,Cd,Ba,Tl and Pb were 0. 28,14,0. 054,0. 20,2. 1,0. 017,0. 10,3. 3,0. 009 4 and0. 33 mg / kg,respectively,whose concentrations were the main sources of uncertainties. CONCLUSION In the drawing of standard curves of C. chinensis,larger range of pipette and less dilution steps should be chosen to increase the accuracy.
出处
《中成药》
CAS
CSCD
北大核心
2016年第10期2208-2215,共8页
Chinese Traditional Patent Medicine
基金
国家科技重大专项课题(2014ZX09304307-002)
关键词
黄连
重金属元素
不确定度
ICP-MS
Coptis chinensis Franch.
heavy metal elements
uncertainties
ICP-MS
