淋巴结阳性率在ⅠB～ⅡA期宫颈癌患者中的临床意义

Significance of lymph node ratio in stage IB to IIA cervical cancer

目的:研究淋巴结阳性比率(LNR)对IB^IIA期宫颈癌患者无进展生存期(PFS)及总生存期(OS)的影响。方法:回顾分析2010年1月~2015年12月我院收治的102例经根治性子宫切除±双侧卵巢切除+盆腔淋巴结清扫±腹主动脉淋巴结清扫术的淋巴结转移阳性的102例IB^IIA期宫颈癌患者的临床资料。采用单因素和多因素分析LNR、分期、病理类型、组织学分级、肿瘤大小、辅助治疗对PFS及OS的影响。结果:单因素分析显示,LNR、分期对PFS、OS有显著影响。多因素分析显示,LNR>10%的患者PFS更差(HR=0.151,P=0.047,95%CI为0.023~0.974);而LNR>10%患者的OS与LNR≤10%者比较,差异无统计学意义。结论:LNR可以作为判断IB^IIA期宫颈癌患者PFS的一项独立危险因素。

Objective：To evaluate lymph node ratio （ LNR） in predicting the progres-sion-free-survival （PFS） and overall survival （OS） in stage IB to IIA cervical cancer. Meth-ods：Respective study of 102 cases of patients diagnosed with node-positive stage I or II cervical cancer who underwent radical hysterectomy ＋/- bilateral ovarian resection and plevic ＋/-para-aortic lymphadenectomy in the Tumor Hospital Affiliated to Xinjiang Medical University from Jan. 2010 to Dec. 2015. To evaluate the prective value of factors including LNR,stage, pathological type,histological grade,tumor size and adjunctive therapy for PFS and OS by uni-variate and multivariate analyses. Results：Univariate analyse showed that LNR and stage were identified as prognostic factors for PFS and OS. A LNR 〉10% was associated with a worse PFS （HR=0. 151,P=0. 047,95%CI：0. 023~0. 974）,but showed no significant differcence with a worse OS on multivariate analysis. Conclusions：LNR can be an independent prognostic param-eter for PFS of stage IB to IIA cervical cancer patients.