中药汤剂联合静脉化疗方案对结直肠癌患者细胞免疫功能影响的Meta分析

Meta-analysis of Chemotherapy Combined with Traditional Chinese Medicine Decoction in Cellular Immunity of Patients with Colorectal Cancer

目的:比较中药汤剂联合静脉化疗方案和单独使用静脉化疗方案对结直肠癌患者细胞免疫功能的影响。方法:检索2010年1月—2015年10月有关比较中药汤剂联合静脉化疗方案和单独使用静脉化疗方案对结直肠癌患者细胞免疫功能影响的随机对照研究的中英文文献。评价纳入文献质量,并进行Meta分析。结果:经严格筛选,最终纳入21篇随机对照文献,涉及1267例患者,其中中药汤剂联合静脉化疗方案组638例,单独使用静脉化疗方案组629例。Meta分析结果显示:与单独使用静脉化疗方案相比,中药汤剂联合静脉化疗方案在改善CD3_^+、CD4_^+、NK、CD4_^+/CD8_^+比值方面有统计学意义,在改善CD8_^+方面无统计学意义。结论:中药汤剂联合静脉化疗方案可以改善结直肠癌患者的细胞免疫功能,但还需要大量的多中心随机对照临床试验加以证实。

Objective： To compare the impacts between chemotherapy combined with traditional Chinese medicine decoction and chemotherapy on cellular immunity function in treatment of colorectal cancer. Methods： Literature of randomized controlled trials,published between January 2010 and October 2015 in both Chinese and English,comparing the influences between chemotherapy combined with traditional Chinese medicine decoction and chemotherapy on cellular immunity function in treatment of colorectal cancer were searched. Evaluation of the quality of literature and the Meta-analysis were carried on. Results： After strict screening,a total of 21 pieces of literature of randomized controlled trials were selected finally,involving 1267 patients,with 638 cases in chemotherapy combined with traditional Chinese medicine decoction group and 629 cases in chemotherapy group. Results of Meta-analysis showed that chemotherapy combined with traditional Chinese medicine decoction group was statistically significant in improving CD3_~＋,CD4_~＋,NK,the ratio of CD4_~＋/ CD8＋,comparing with chemotherapy group. There was no significant difference in improving CD8＋. Conclusion： Chemotherapy combined with traditional Chinese medicine decoction can improve the cellular immunity function,but still need a lot of randomized controlled trials from multi-center to identify.