补肺固表方对咳喘慢性持续期肺功能及气道炎症的影响研究

Effect of Bufei Gubiao Prescription on Pulmonary Function in Cough Asthma Chronicity-Persistent Period and Airway Inflammation

目的:研究补肺固表方对咳喘慢性持续期肺功能及气道炎症的影响。方法:随机双盲法将符合纳入条件的80例咳喘慢性持续期患者分为两组,各40例,对照组采取常规西医治疗,观察组在对照组基础上行补肺固表方治疗,比较两组临床疗效、治疗前后中医证候总积分、肺功能、血清相关指标及SGRQ评分情况。结果:观察组总有效率95.0%,较对照组的75.0%差异有统计学意义(P<0.05)。两组治疗后中医证候总积分、ECP、Ig E、SGRQ评分较治疗前明显下降(P<0.05);两组治疗后FEV1、FEV1/FVC、PEF、IFN-γ较治疗前明显上升(P<0.05);观察组上述指标治疗后均明显优于对照组(P<0.05)。结论:补肺固表方能明显减轻患者气道炎症反应及临床症状,促进患者肺功能恢复,可作为咳喘慢性持续期治疗的重要手段。

Objective： To study the effect of Bufei Gubiao Prescription on pulmonary function in cough asthma chronicity-persistent period and airway inflammation. Methods： Eighty patients in cough asthma chronicity-persistent period conforming to the conditions of admission were divided into two groups by randomized double-blind method with 40 cases in each. The control group was treated with conventional western medicine while the observation group with Bufei Gubiao Prescription based on the treatment of the control group. The clinical curative effect,the total scores of TCM symptoms before and after the treatment,pulmonary function,serum related indexes and SGRQ scores were compared between the two groups. Results： The total effective rate of the observation group was 95%. Compared with 75. 0% of the control group,the difference was statistically significant（ P〈0. 05）. After treatment,the total scores of TCM symptoms,ECP,Ig E and SGRQ scores of the two groups decreased significantly（ P〈0. 05）,FEV1,FEV1/ FVC,PEF and IFN-γ in the two groups after the treatment increased significantly（ P〈0. 05）. After treatment,the above parameters in the observation group were significantly better than those of the control group（ P〈0. 05）. Conclusion： Bufei Gubiao Prescription can significantly reduce the airway inflammatory response and clinical symptoms and promote the recovery of pulmonary function of patients,which can be taken as an important means for the treatment of patients in cough asthma chronicity-persistent period.