术前区域性化疗联合营养支持对胃癌根治术效果及组织中的PRR11蛋白表达的影响

Effects of Preoperative Regional Chemotherapy Combined with Nutritional Support on Effectiveness of Radical Resections of Gastric Cancer and Expressions of PRR11 Protein in Tissues

目的分析术前区域性化疗联合营养支持对胃癌手术疗效及组织中PRR11蛋白表达的影响。方法选择2011年1月—2015年2月收治的接受胃癌根治术的76例,按治疗方式分为联合组40例和化疗组36例。化疗组单纯给予术前区域性化疗,联合组在此基础上给予营养支持干预。观察两组机体组成变化、临床效果及组织中PRR11蛋白表达情况,记录毒副反应、并发症及复发情况。结果联合组术前体重、肌肉群(MM)高于化疗前,化疗组术前体重、MM低于化疗前,且联合组术前体重、MM、脂肪群(FM)、瘦组织群(LBM)、全身水量(TBM)均高于化疗组(P<0.05);联合组化疗总缓解率、手术根治率及术后情况比较差异无统计学意义(P>0.05);联合组消化道反应、骨髓抑制、过敏反应发生率低于化疗组(P<0.05);两组术前、术后PRR11蛋白表达阳性率均低于化疗前,且联合组低于化疗组,但差异无统计学意义(P>0.05);两组术后并发症发生率及复发率比较差异无统计学意义(P>0.05)。结论采用术前区域性化疗联合营养支持可提高胃癌手术治疗效果,减少化疗毒副反应,改善患者营养状况,降低PRR11蛋白表达。

Objective To analyze effects of preoperative regional chemotherapy combined with nutritional support on effectiveness of radical resection of gastric cancer and expressions of PRR11 protein in tissues. Methods A total of 76 patients undergoing radical resection of gastric cancer during January 2011 and February 2015 were divided into combination group（ n = 40） and chemotherapy group（ n = 36） according to treatment methods. Chemotherapy group received preoperative regional chemotherapy only,while combination group received nutritional support intervention on the basis of treatment for chemotherapy group,and then in the two groups,body composition changes,clinical effectiveness and PRR11 protein expressions in tissues were observed,and toxic and side effects,complications and recurrence were recorded. Results Values of body weigh and muscle mass（ MM） before operation were higher than those before chemotherapy in combination group,while the preoperative values were lower than those before chemotherapy in chemotherapy group,and preoperative values of body weight,MM,fat mass（ FM）,lean body mass（ LBM） and total body water（ TBW） were higher in combination group than those before chemotherapy in chemotherapy group（ P〈0. 05）; there were no significant differences in total remission rate,radical cure rate and postoperative condition after chemotherapy between two groups（ P〉0. 05）. Incidence rates of digestive tract reactions,bone marrow depression and allergic reactions in combination group were lower than those in chemotherapy group（ P〈0. 05）. Levels of PRR11 protein expression before and after operation were lower than those before chemotherapy in two groups,and the levels in combination group were lower than those in chemotherapy group,but the differences were not statistically significant（ P〉0. 05）. There was no significant difference in postoperative rates of complication and recurrence in two groups（ P〉0. 05）. Conclusion Preoperative regional chemotherapy combined with nutritional support can improve surgical effectiveness,reduce toxic and side effects induced by chemotherapy,improve patients＇ nutritional status and reduce expression of PRR11 protein in patients with gastric cancer.