奥拉西坦治疗急性重型颅脑损伤合并创伤性休克效果观察

Effect Observation of Oxiracetam in Treatment of Patients with Acute Severe Craniocerebral Injury Combined with Traumatic Shock

目的观察奥拉西坦辅助治疗急性重型颅脑损伤合并创伤性休克患者的临床疗效。方法回顾性分析2014年1月—2015年12月收治的急性重型颅脑伤合并创伤性休克70例的临床资料,按治疗方法分为观察组和对照组,每组35例。对照组予常规治疗,观察组在对照组基础上加用奥拉西坦注射液。分别于治疗前后测评格拉斯哥昏迷量表(GCS)评分,同时行CT灌注成像(CTPI)检查,检测脑血流量(CBF)、平均通过时间(MTT)。治疗14 d后评价两组临床疗效。治疗1个月后测评格拉斯哥预后(GOS)评分。结果观察组总有效率高于对照组,GCS评分、CBF、MTT、GOS评分改善情况均优于对照组(P<0.05)。结论奥拉西坦治疗重型颅脑损伤合并创伤性休克具有良好疗效,能改善脑微循环,促进脑功能恢复。

Objective To observe clinical effect of Oxiracetam in treatment of patients with acute severe craniocerebral injury combined with traumatic shock. Methods Clinical data of 70 patients with acute severe craniocerebral injury combined with traumatic shock admitted during January 2014 and December 2015 was retrospectively analyzed,and the patients were divided into control group and observation group（ n = 35 for each group） according to therapic methods. Control group was given conventional treatment,while observation group was added with Oxiracetam injection on the basis of conventional treatment. Glasgow Coma Scale（ GCS） and CT perfusion imaging（ CTPI） examinations were performed before and after treatment to detect cerebral blood flow（ CBF） and mean transit time（ MTT）. Clinical effects were evaluated 14 d after treatment,and Glasgow Outcome Scale（ GOS） was performed 1 month after treatment in two groups. Results In observation group,total efficiency rate was significantly higher,while improvement conditions of GCS score,CBF,MTT and GOS scores were better than those in control group（ P〈0. 05）. Conclusion Oxiracetam in treatment of patients with acute severe craniocerebral injury combined with traumatic shock can achieve good curative effect,improve brain microcirculation and promote recovery of brain function.