郁金消银汤联合卡泊三醇治疗银屑病的效果及对外周血IFN-γ、IL-2、IL-4和IL-10的影响

Effect of IFN-γ, IL-2, IL-4 and IL-10 in Peripheral Blood of Patients with Psoriasis Treated by Turmeric Silver Soup Joint Calcipotriol

目的探讨卡泊三醇治疗银屑病的效果及对患者外周血细胞因子的影响作用。方法选取本院皮肤性病门诊2013年1月—2015年1月收治的120例确诊寻常型银屑病患者进行回顾性分析,其中对照组72例患者仅采用郁金消银汤进行治疗,观察组48例在对照组基础上加用了卡泊三醇涂于患处,2组患者疗程均为12周。结果治疗后2组患者的外周血IFN-γ、IL-2、IL-4和IL-10水平、银屑病面积和严重程度指数(PASI)评分与本组治疗前比较均显著的降低(P<0.05),治疗后,观察组的外周血IFN-γ、IL-2、IL-4和IL-10水平、PASI评分显著的低于同期对照组患者(P<0.05);治疗后观察组的治愈率62.50%显著的高于对照组的41.67%(P<0.05)。结论卡泊三醇辅助治疗银屑病的临床效果更佳,可能与进一步减少患者外周血细胞因子释放有关。

Objective In order to investigate the effect of calcipotriol combined with turmeric Xiaoyin soup in the treatment of psoriasis and the effect on peripheral blood cell factors in patients. Methods Selected 120 patients with psoriasis vulgaris treated in our hospital from January 2013 to January 2015 were retrospectively analyzed. Seventy-two patients in control group were only treated with turmeric Xiaoyin soup, 48 cases in observation group were treated with turmeric Xiaoyin soup combined with calcipotriol. The course of treatment was 12 weeks in 2 groups. Results After treatment, the peripheral blood IFN-, IL-2, IL-4, IL-10, and PASI scores of the 2 groups were significantly decreased（P〈0.05）. And the peripheral blood IFN-, IL-2,IL-4, IL-10 and PASI scores of the observation group were significantly lower than those of the control group（P〈0.05）. The cure rate of the observation group（62.50%） was significantly higher than that of the control group after treatment（41.67%, P〈0.05）. Conclusion The clinical effect of adjuvant therapy with calcipotriol in the treatment of psoriasis is better, which may be related to the release of cytokines in peripheral blood of patients.