生酮饮食抑制炎症反应机制的研究进展

Update on anti-inflammation mechanism of ketogenic diet

生酮饮食可用于治疗一些炎症诱导的癫痫性综合征，其机制复杂，主要通过多个靶点发挥抑制病原体、控制炎症、调节免疫等作用。动物模型研究发现，生酮饮食喂养可明显缩短局部炎症引起的红、肿、热的时间，并降低循环中花生四烯酸的水平。研究表明，生酮饮食主要通过抑制Nod样受体蛋白3炎症小体、核因子kappa B和氧自由基的释放，提高过氧化物酶增殖体激活型受体叮的水平，共同达到抗炎的效果。该文对生酮饮食的抗炎机制及其临床应用的进展作一综述。

The ketogenic diet （KD） is an effective treatment for refractory epilepsy,including some inflammation-induced epileptic encephalopathies, and the mechanism of it is complicated. KD, through multiple targets, plays the role to inhibit pathogens, control inflammation and regulate immune function. In experiments, KD provides an anti-inflammatory effect in some rat models of fever. It has been shown that, KD decreases peripheral edema, attenuates thermal nociception and reduce arachidomic acid level in circulation. KD blocks Nod-like receptor protein 3 （ NLRP3 ）, nuclear factor-kappa B （ NF-κB ）, oxygen free radicals, and improves Peroxisome proliferator-actived Receptor（PPAR） γ level ,to reach the effect of anti-inflammatory. This review focuses on ketogenic diet anti-inflammatory mechanism and the recent advances in clinical application.