摩根摩根菌临床分布及耐药性分析

Clinical distribution and antimicrobial resistance of Morganella morganii

目的分析摩根摩根菌的临床分布特点及耐药现状,为抗感染治疗提供参考依据。方法对医院2013年7月-2015年6月临床分离的80株摩根摩根菌的来源与耐药性进行回顾性分析,并对痰液标本与其他类型标本分离到的摩根摩根菌对抗菌药物的耐药情况进行统计学比较。结果多种临床标本均可分离到摩根摩根菌,以痰液标本居多,占58.75%;科室分布以ICU为主,占41.25%,其次为急诊内科,占31.25%。20种抗菌药物中,敏感性较高的药物为丁胺卡那霉素(98.75%)、头孢吡肟(91.25%)、氨曲南(87.50%)、亚胺培南(86.25%);痰液标本与其他标本分离到的摩根摩根菌对头孢哌酮/舒巴坦、头孢他啶、头孢曲松、头孢吡肟、厄他培南、亚胺培南、庆大霉素、环丙沙星、复方新诺明等9种抗菌药物有显著性差异(P<0.05)。其他标本分离到的摩根摩根菌对此9种药物的敏感性要显著高于痰液标本分离到的摩根摩根菌。结论对摩根摩根菌引起的感染应合理使用抗菌药物早期治疗,避免耐药菌株的产生;不同部位的摩根摩根菌感染应选用不同种抗菌药物,以提高治疗效果。

Objective To analyze the clinical distribution and drug resistance of 80 strains of Morganella morganii so as to provide references for anti-infection treatment.Methods A retrospective analysis was done on 80 strains of Morganella morganii which were isolated from hospitalized patients from Jul 2013 to Jun 2015,and drug resistances were compared between the strains isolated from sputum specimens（47）and other specimens（33）.Results Morganella morganii were isolated from various specimens,most of which were isolated from sputum specimens,and from ICU and Emergency Department.The drug susceptibility of Morganella morganii against amikacin（98.75%）,cefepime（91.25%）,aztreonam（87.50%）and imipenem（86.25%）were high.There were statistically significant differences in the drug resistances to9 antibacterial drugs（cefoperazone/sulbactam,ceftazidime,ceftriaxone,cefepime,ertapenem,imipenem,gentamycin,ciprofloxacin and SMZ-TMP）between the strains isolated from sputum specimens and those from other specimens（P〈0.05）,and the drug sensitivity to the strains isolated from other specimens is significantly higher than the strains isolated from sputum specimens.Conclusion Clinicians should use antibiotics rationally to prevent drug resistance and adopt suitable drugs to treat the infections of Morganella morganii in different body part.