Th细胞与吸烟、被动吸烟所致肺部疾病的研究进展

Th cells and smoking/passive smoking associated lung diseases:Advance in research

T辅助细胞(Th)根据功能不同可分为Th1、Th2和Th17三个亚群,Th1细胞主要分泌γ-干扰素(IFN-γ)、白细胞介素-2(IL-2)等,促进细胞免疫;Th2细胞分泌白细胞介素-4、-5、-6、-10、-13(IL-4、IL-5、IL-6、IL-10、IL-13)等,促进体液免疫。正常情况下Th1/Th2处于平衡状态,其平衡变化是体内炎症反应与抗炎反应免疫平衡变化的基础,与疾病发生和预后关系密切。Th17通过分泌白细胞介素-17参与固有免疫和某些炎症反应。Th细胞在炎症所致的诸多疾病的形成、发展及转归中发挥巨大作用。研究证明吸烟可促进炎症形成而致多系统疾病,特别是肺部疾病,这与T细胞分化和Th细胞分泌细胞因子的状态相关,本文对Th细胞与吸烟所致肺部疾病相关性的研究成果进行综述。

T helper（Th）cells can be divided into Th1,Th2 and Th17according to their different functions.Th1 cells mainly secreteγ-interferon（IFN-γ）and interleukin-2（IL-2）to promote cellular immunity,while Th2 cells secrete interleukin-4,-5,-6,-10and-13（IL-4,IL-5,IL-6,IL-10,IL-13）to promote humoral immunity.Under normal circumstances there is an equilibrium between Th1 and Th2,which is the basis of the changes in the balance between inflammation and anti-inflammatory response in the body,and is closely correlated with the occurrence and prognosis of diseases.Th17 participates in innate immunity and certain inflammatory reactions through secretion of interleukin-17.Th cells play a huge role in the formation,development and outcome of many diseases caused by inflammations.Studies have shown that smoking contributes to the incidence of inflammation,resulting in multi-system diseases,especially lung diseases.This is associated with the differentiation of T cells and cytokines secretion by Th cells.This paper reviewed the results of researches on the relevance between Th cells and lung diseases caused by smoking.