长沙地区1386例非酒精性脂肪性肝病患者中医体质分布特征及其与血压、体重指数、血脂、肝功能酶学的相关性研究

Study on the distribution characteristics of TCM constitution and its correlation with laboratory indexes of 1386 NAFLD patients in Changsha area

目的:探讨长沙地区非酒精性脂肪性肝病(NAFLD)患者中医体质分布特征及其与血压、体重指数、血脂、肝功能酶学指标的相关性。方法:采取多阶段整群随机抽样的方法对来自于长沙地区工薪阶层的体检人群进行中医体质类型的抽样调查。结果:NAFLD患者的中医体质分布为:平和质42.9%、痰湿质17.1%、湿热质10.2%、阳虚质9.9%、气虚质6.2%、阴虚质6.0%、气郁质4.5%、血瘀质1.9%、特禀质1.3%;NAFLD患者中医体质与体重指数(BMI)、血压、甘油三酯(TG)、(HDL)、高密度脂蛋白(ALT)、丙氨酸转氨酶(GGT)、存在相关性(P值均<0.05);痰湿质与BMI(P<0.01)、舒张压(P<0.05)呈正相关,与HDL(P=0.007)呈负相关;湿热质与GGT(P<0.01)呈正相关,与HDL(P<0.05)呈负相关。结论:长沙地区NAFLD患者中医体质分布以平和质、痰湿质、湿热质、阳虚质为主,存在兼夹体质;不同NAFLD中医体质类型的BMI、血压、TG、HDL、GGT有不同程度的变化;中医体质类型中以痰湿质、湿热质相关指标的异常最为显著。①痰湿质与BMI、舒张压呈正相关,与HDL呈负相关;湿热质与GGT呈正相关,与HDL呈负相关。

Objective：To explore the distribution characteristics of non alcoholic fatty liver （NAFLD） in Changsha and its correlation with blood pressure, body mass index, blood lipids and liver function enzymes. Methods： Multi stage cluster random sampling method was adopted to investigate the physical fitness of the population in Changsha area. Results： （ 1 ） The distribution of TCM Constitution constituent ratio of NAFLD as follows ：Peaceful quality 42.9%, phlegmy wet quality 17.1%, hot-humid quality 10.2%, Yang deficiency 9.9%, qi deficiency 6.2%, Yin deficiency 6.0%, qi depression 4.5%, blood stasisl. 9% and special intrinsic quality of 1.3%. （2） BMI, blood pressure, TG, HDL, ALT, GGT has a relativity（ All of P 〈 0.01 ） to NAFLD TCM Constitution;The correlation between NAFLD main body constitution and related indexes is as follows ：①Phlegm dampness was positively correlated with BMI（ Exp （β） = 1. 075, P 〈 0.01 ） , diastolic blood pressure （ Exp （β） = 1. 024, ： P = 0. 042）, and negatively correlated with HDL （ Exp （β） = 0. 975, P = 0. 007 ） ; ②Damp-heat constitution was positive- ly correlated with GGT （ Exp （β） = 1. 009, P 〈 0.01 ） and negatively correlated with HDL （ Exp （ β ） = 0. 978, P = 0. 045 ）. Conclusion ： （ 1 ） Distribution of TCM constitution in patients with NAFLD in changsha, with gentle quality, phlegmy wet mass, damp and hot, Yang deficiency quality were given priority to;and there are second TCM Constitution;Among them second TCM Constitution is given priority to with hot and humid, phlegm wet mass. （2） Different NAFLD TCM constitution types of BMI, TG, HDL, blood pressure and GGT have different degrees of change ; In the TCM Constitution of phlegm dampness, damp heat index anomaly is the most significant. ①Phlegmy wet mass was positively correlated with BMI, diastolic blood pressure; And negatively correlated with HDL;②Damp-heat constitution was positively correlated with GGT;And negatively correlated with HDL.