瘢痕疙瘩发病相关的遗传及基因多态性研究进展

The Research Progress of Genetic and Gene Polymorphisms Associated with Keloid Onset

瘢痕疙瘩(KD)是病理性瘢痕的一种,其发病机制十分复杂,目前对其治疗仍无突破性进展。KD在各人种间的遗传异质性、易感变异效应各不相同,其发病机制涉及多条染色体上的多个基因位点,且可能有特异的基因变异参与其中。同时,有多个基因通路参与KD的发病过程,而对其发病过程中不同基因突变及遗传变异进行深入的研究,将有助于KD的个性化诊断和治疗。

Keloid（KD） is a kind of pathological scars,with very complex pathogenesis,and there is still no breakthrough in the treatment. KD susceptibility is variational between different kinds of genetic heterogeneity. Its pathogenesis not only involves multiple gene loci on chromosome, but is also related to the possible specific gene variants. It has more than one gene pathway involved in the pathogenesis of KD, and in-depth study on the onset of different gene mutation and genetic variation will contribute to the individualized diagnosis and treatment of KD.