鼻咽癌放疗后早期放射性脑损伤的功能磁共振成像研究进展

Research Progress of Functional Magnetic Resonance Imaging of Radiation-induced Brain Injury after Nasopharyngeal Carcinoma Radiotherapy

放射治疗是鼻咽癌患者的主要治疗方法,治疗过程中常常引起患者不同程度的放射性脑损伤。大部分患者在放疗结束后的长期随访观察中常规磁共振成像(MRI)及CT检查并无异常的信号或密度改变。但是,当出现CT及常规MRI可见的影像学改变时,损伤往往已较为严重,临床缺乏有效的治疗手段,治疗效果差,严重影响鼻咽癌患者的预后。因此,如何在潜伏期内检出放射性脑损伤,对改善患者的预后意义重大。

Radiotherapy is the main treatment of nasopharyngeal carcinoma, which often causes different degrees of radiation brain injury in the process of treatment. The majority of patients have no abnormal signal or density change of the conventional MRI and CT examination in the long-term follow-up after radiation therapy. However,when there is a visible CT and conventional MR imaging changes,the damage often has been severe and lack of effective treatments, or with poor clinical treatment effect, seriously influencing the progno- sis of patients. Therefore, how to detect radiation brain injury during latent period is of great significance to improve the prognosis of the patients.