摘要
目的探讨职业女性生殖道高危型人乳头瘤病毒(HPV)感染自然清除情况及其影响因素。方法对初次检测高危型HPV阳性的196例职业女性进行为期2年的随访检测,探讨各因素与宫颈高危型HPV持续感染的关系。结果 196例女性的生殖道高危型HPV自然清除率为73.47%(144/196),中位数时间为13.6个月,持续感染率为19.39%(38/196),进展率为7.14%(14/196)。年龄、避孕方式、初始病毒载荷量以及患有生殖道炎症是高危型HPV自然清除的影响因素(χ^2=15.478、5.439、8.007、37.692,P〈0.05);与女性文化程度、初次性生活年龄及初始细胞学结果无明显相关性(χ^2=0.568、0.415、0.788,P〉0.05)。结论大多数职业女性生殖道高危型HPV感染可在2年内被自然清除。对于无症状、低病毒载荷量的高危型HPV感染者宜密切随访,避免过度治疗。
[Objective] To investigate the natural clearance rate and influencing factors of high-risk human papillomavirus(HPV)infection in genital tract of professional women. [Methods]196 professional women who were positive for high-risk HPV in the first examination were followed up for 2 years,to explore the factors influenced the persistent infection of high-risk HPV.[Results]The natural clearance rate of high-risk HPV was 73.47%(144/196),with the median viral clearance time of 13.6 months. The persistent infection rate was 19.39%(38/196) and the progress rate was 7.14%(14/196). Age,contraceptive methods,initial viral load and reproductive tract inflammation were the influencing factors of natural clearance of high-risk HPV(χ^2=15.478,5.439,8.007,37.692,P〈0.05). While there were no significant correlations between the natural clearance and education level,age of the first sexual experience,the initial cytology results(χ^2=0.568,0.415,0.788,P〉0.05).[Conclusion]Most of high-risk HPV infection in genital tract among professional women can be cleared naturally within 2 years. The over treatment should be avoided for high-risk HPV infection cases with asymptomatic or low viral load.
出处
《职业与健康》
CAS
2016年第18期2533-2536,共4页
Occupation and Health
基金
河北省医学科研重点课题计划(20150823)
关键词
人乳头瘤病毒
自然清除
影响因素
High-risk human papillomavirus(HPV)
Natural clearance
Influencing factors