血清乳酸脱氢酶检测在巨幼细胞性贫血诊断中的意义

Significance of serum lactate dehydrogenase in the diagnosis of megaloblastic anemia

目的探讨血清乳酸脱氢酶(LDH)检测在巨幼细胞性贫血(MA)诊断中的意义。方法选取MA患者32例为MA组,骨髓异常增生综合征(MDS)患者22例为MDS组,另选取体检的健康人员24例为对照组,检测其生化指标并进行比较。结果 MA组患者的LDH水平、总胆红素、直接胆红素、间接胆红素和同型半胱氨酸水平与MDS组、对照组比较均有显著差异(P<0.01)。MA组LDH升高的阳性率高于MDS组,差异显著(P<0.01)。结论血清乳酸脱氢酶是巨幼细胞性贫血的敏感指标,可作为诊断该病的常规检验指标之一,对于鉴别该病与未伴有原始细胞增多的骨髓异常增生综合征具有重要意义。

Objective To investigate the significance of serum lactate dehydrogenase in the diagnosis of megaloblastic anemia. Methods Thirty-two cases patients with MA were selected as group MA, 22 cases patients with MDS were selected as group MDS; 24 cases of heahh person were selected as control group. The biochemical indicators were tested and compared between three groups. Results The levels of serum lactic dehydrogenase （LDH）, total bilirubin （TBIL）, direct bilirubin （DBIL）, indirect bilirubin （IBIL） and homoeysteine （Hcy） level were significantly different among three groups （P〈0.01）. The positive rate of LDH increasing in MA was significantly higher than in MDS （P〈0.01）. Conclusion Serum LDH is a sensitive index of MA, which can be used as one of the routine test indexes for diagnosis of this disease.