经皮穴位电刺激预防开颅手术术后恶心呕吐的随机对照研究

Preventive effect of transcutaneous acupoint electrical stimulation in treating postoperative nausea and vomiting in patients undergoing craniotomy-a randomized controlled trial

目的 观察内关穴联合足三里穴经皮穴位电刺激（TAES）对神经外科开颅手术患者术后恶心呕吐（PONV）发生率的影响。方法 择期行开颅手术患者100例,随机分为对照组（50例）、TAES组（50例）。所有患者手术结束前静脉推注阿扎司琼10mg,TAES组在术后电刺激双侧内关穴及足三里穴30min。记录患者术后0~2、2~6、6~24及24h内PONV发生情况。结果 100例患者中有92例患者完成并纳入实验。对照组和TAES组分别有24例（55.3%）和15例（33.3%）发生恶心呕吐。与对照组比较,TAES组术后0~2hPONV的发生率差异无统计学意义,术后2~6、6~24及24h内PONV的发生率降低,差异有统计学意义（P〈0.05）。结论 在常规治疗的基础上,内关穴联合足三里穴经皮穴位电刺激能进一步降低开颅手术患者PONV的发生率。

Objective To observe the effect of Neiguan （PC6） and Zhigou （ SJ6） transcutaneous acupoint electrical stimulation （TAES） in preventing postoperative nausea and vomiting （PONV） after craniotomy. Methods One hundred patients, who underwent craniotomy surgery, were randomly divided into two groups： control group （n = 50）, TAES group（n= 50）. All patients were given routine intravenous azasetron hydrochloride 10 mg before the end of operation. TAES group received TAES at bilateral Neiguan（ PC6 ）and Zhigou（SJ6） lasted for 30 rain after surgery. The occurrence of PONV was recorded within 2 h after operation, during 2 -6 h and 6 - 24 h after operation, and within 24 h after operation. Results Among the initial 100 patients, 92 completed the study and were subordinated to the final analysis. The PONV incidences of the control group and TAES group were 55.3% and 33.3%. Compared with the control group, there were no significant differences in the incidence of PONV within 0 - 2 h postoperatively. The incidence of PONV within 2 - 6 h, 6 - 24 h and 24 h after operation were significantly decreased in TAES group （P 〈 0. 05）. Conclusion TAES Neiguan （PC6） and Zhigou （ SJ6） on the basis of routine treatment can further decrease the occurrence of PONV in patients undergoing craniotomy.