摘要
胰高血糖素及其类似物是由小肠L细胞分泌的一种肠促胰岛素，能顺利透过血脑屏障进入脑组织发挥神经保护作用。利拉鲁肽与胰高血糖素及其类似物具有较高的同源性，进入脑组织后能与相关受体结合并激活Nrf22／HO-1信号通路，进而减少氧化应激产物生成，提高谷胱甘肽、血红素氧合酶、超氧化物歧化酶等Ⅱ相解毒酶，促进血管生成，从而保护糖尿病合并脑缺血损伤的神经细胞。
Glucagon and its analogues are a intestinal stimulating insulin screened by the small intestinal L cells. It can smoothly penetrate the blood-brain barrier into the brain tissue and play a neuropro- tective role. Liraglutide and gtucagon and its analogues have higher homology. After entering the brain tissue, it is able to bind with the related receptors and activates Nrf2/HO-1 signaling pathway and thus reducing the production of oxidative stress products, increases the glutathione, heme oxy gen synthase, superoxide dismutase and other phase Ⅱ detoxification enzymes, promotes angiogenesis, and protects the nerve cells of diabetes combined with cerebral ischemia injury.
出处
《国际脑血管病杂志》
2016年第8期765-768,共4页
International Journal of Cerebrovascular Diseases
