摘要
研究了用静电纺丝制备聚苯乙烯-马来酸酐共聚物(SMA)/醋酸纤维素(CA)复合超细纤维。通过一缩二乙二醇(DEG)交联,并在0.05mol/L NaOH/乙醇溶液中水解制得SMA-Na-DEG/纤维素超细纤维水凝胶。对其结构和拉伸性能进行了分析和测试,结果表明:该水凝胶pH响应良好,pH=9.1时,溶胀比达到最大值27.6g/g;加入纤维素后,水凝胶的力学性能明显提高。此外,还以水杨酸为药物,评估了SMA-Na-DEG/纤维素水凝胶的药物释放行为,并探讨了其释放机理。
Poly[styrene-co （maleic anhydride）I/acetate cellulose （SMA/CA） composite ultrafine fibers were fabri- cated by electrospinning. SMA-Na DEG/cellulose ultrafine fiber hydrogels were obtained using diethylene glycol （DEG） as crosslinker,and following hydrolyzed in 0.05mol/L NaOH/ethanol solutions. They were pH responsive, and the water swelling ratio reached a maximum of 27.6g/g at pH = 9.1. Compared with SMA-Na-DEG fibers hydrogels, the rigidity, Young＇s modulus and elongation of SMA Na DEG/cellulose hydrogels increased,respectively. At last,the drug release be- havior of SMA-Na-DEG/cellulose hydrogels was evaluated,and mechanism of release was investigated. Key words poly]-styrene-co-（maleic sodium anhydride）],composite fiber,pH responsivity,hydrogel,drug release
作者
刘瑞来
曹胜光
饶瑞晔
唐春怡
Liu Ruilai Cao Shengguang Rao Ruiye Tang Chunyi(College of Ecological and Resource Engineering,Fujian Provincial Key Laboratory of Eco-Industrial Green Technology,Wuyi University,Wuyishan 354300 College of Material Science and Engineering,Fujian Normal University,Key Laboratory of Polymer Materials of Fujian Province,Fuzhou 350007 College of Biological and Chemical Engineering, Guangxi University of Science and Technology,Liuzhou 545006)
出处
《化工新型材料》
CAS
CSCD
北大核心
2016年第10期200-203,共4页
New Chemical Materials
基金
国家自然科学基金(51406141)
福建省教育厅A类(JA13320)
广西省自然科学基金(2013GXNSFBA019036)
关键词
聚苯乙烯-马来酸钠
复合纤维
PH响应
水凝胶
药物释放
poly[styrene-co- （maleic sodium anhydride） ], composite fiber, pH responsivity, hydrogel, drug release
