摘要
阿尔兹海默症(Alzheimer's disease,AD)俗称老年痴呆,是一种较为常见的慢性进行性神经退行性疾病,主要表现为全脑性不可逆转性脑功能损害。其病因复杂,故发病机制尚不明确。现如今研究的其中一种理论认为Tau蛋白的异常聚合会和束状细丝(straight filament,SF)一同组成神经元纤维缠结(neurofibrillary tangles,NFTs),导致神经纤维内的微管变形,从而导致神经元变性甚至死亡。大量的神经元的死亡会导致AD的发生。因此,有必要摸清Tau蛋白异常磷酸化的机理来对患者进行有针对性的治疗。
Alzheimer＇s disease is a kind of common chronic progressive neurodegenerativing disease,primarily manifested as irreversible whole brain damage. Because of complicated factors,nosogenesis has not been determined. One kind of theory is that abnoraml Tau protein phosphorylation and straight filament will lead to NFTs. This caused microtubule deformation in the neurofibrillary. Then neuronal will degeneration and even death. When lots of neuronal death that would trigger AD. Therefore it＇s important to find out the mechanism of abnormal phosphorylation of Tau protein and then targeted therapy for patients.
出处
《中国老年保健医学》
2016年第5期8-11,共4页
Chinese Journal of Geriatric Care
基金
国家自然科学基金(81061120527,81370445,81472408)
卫生部公益性研究基金(201302008)
国家科技部十二五支撑计划(2012BAI10B01,2015BAI06B03)
