可生物降解交联聚合物的研究进展

Progress in Research of Biodegradable Cross-linked Polymers

交联聚合物具有稳定的三维网络结构,可以提高药物缓释载体的尺寸稳定性。本文综述了可生物降解交联聚合物的研究进展,主要介绍了可生物降解交联聚合物的制备方法,包括交联剂交联、辐照交联、光致交联以及过氧化物交联在制备可生物降解交联聚合物中的应用,详细介绍了交联剂的种类及结构对交联效果的影响、交联后聚合物性能的变化等。最后总结了可生物降解交联聚合物在组织工程支架、药物缓释材料、神经再生修复材料以及形状记忆材料等生物医用领域的应用。

Biodegradable cross-linked polymers have stable 3D network structures with good dimensional stability, and are more suitable to localize drug delivery depots than linear polymers for implanted devices. This paper summarized the progress in the research of the biodegradable cross-linked polymers, and especially discussed the preparation methods including chemical-crosslinking, radiation-crosslinking, photo-crosslinking and oxide-crosslinking. The effect of the crosslinker type and structure on the cross-linkin efficiency and the performance of the cross-linked networks were displayed. At last, this paper summarized the potential applications of the biodegradable cross-linked polymers in biomedical fields, such as tissue engineering scaffold, carriers for drug controlled release and Nerve regeneration as well as shape memory materials.