抗骨质疏松治疗对骨量减少妇女的干预效果

Intervention effect of anti-osteoporosis therapy on osteopenia in women

目的 探讨抗骨质疏松治疗对绝经后骨量减少妇女的干预效果。方法 对31例绝经后骨量减少妇女进行抗骨质疏松治疗,常规给予阿仑膦酸钠、阿法骨化醇或骨化三醇、碳酸钙D3口服,比较治疗前后骨密度和骨代谢标志物的变化。结果 与治疗前相比,治疗6个月后腰椎L1~L4侧位和左股骨颈骨密度均增加,骨钙素、Ⅰ型前胶原N端肽、Ⅰ型胶原交联C端肽水平降低,而25羟基维生素D3水平升高（P〈0.05）。结论 采用抗骨质疏松治疗绝经后骨量减少妇女,能增加腰椎和股骨颈骨密度,有效预防骨量丢失,从而降低骨质疏松性骨折的发生。

Objective To investigate the intervention effect of anti‐osteoporosis therapy on osteopenia in postmenopausal women .Methods A total of 31 postmenopausal women with osteopenia received anti‐osteoporosis therapy including alendronate ,alfacalcidol or calcitriol ,calcium carbonate . The changes of bone mineral density （BMD） and bone metabolism makers were compared before and after treatment .Results Compared with before ,the BMD values of lumbar spine 1‐4 and left femoral neck were increased ,the levels of osteocalcin ,collagen type Ⅰ N‐terminal peptide andβ‐crosslaps were decreased ,and the level of 25‐hydroxyvitamin D3 was gradually increased after treatment for 6 months （P＆lt;0 .05） .Conclusion The anti‐osteoporosis therapy in the treatment of postmenopausal women with osteopenia can effectively increase the BMD values of lumbar spine and femoral neck ,prevent bone loss and decrease the incidence of osteoporotic fractures .