血清白细胞介素-1β、肿瘤坏死因子-α与大骨节病关系的Meta分析

Meta-analysis of IL-1β and TNF-αlevels in the serum of Kaschin-Beck disease patients

目的 采用Meta分析系统评价大骨节病患者血清白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）水平。方法 全面检索国内外公开发表的对大骨节病患者血清IL-1β、TNF-α水平检测分析的文献,根据纳入和排除标准对合格入选文献采用RevMan 5.2软件进行Meta分析。结果 共检索到8篇符合纳入标准的文献,总病例数为291例,健康对照300例。大骨节病患者的血清IL-1β水平明显高于健康对照组标准化均数差（standardized mean difference,SMD）,SMD=1.55,95%CI=0.73-2.37,P〈0.000 01;TNF-α水平亦明显高于健康对照组,SMD=2.49,95%CI=1.49-3.49,P〈0.000 01。结论 大骨节病患者血清IL-1β、TNF-α水平明显增高,其与大骨节病发病的因果关联仍需进一步研究。

Objective To evaluate IL-1β and TNF-α levels in the serum of Kaschin-Beck disease （KBD） patients with Meta-analysis. Methods The literature on detection of IL-1β and TNF-α levels in KBD patients was comprehensively searched and qualified articles were selected based on inclusion and exclusion criteria using RevMan 5.2 software for Meta-analysis. Results We included 8 articles involving totally 291 KBD patients and 300 healthy controls. IL-1β level was significantly higher in the KBD patients than in the healthy controls （SMD=1.55, 95% CI=0.73-2.37, P〈0.00001）. TNF-α level in the KBD patients was also significantly higher than that in the healthy controls （SMD=2.49, 95% CI=1.49-3.49, P〈0.00001）. Conclusion IL-1β and TNF-α levels in KBD patients are significantly increased, but their role in KBD development still requires further study.