非小细胞肺癌患者化疗期间应用经皮穴位电刺激的临床效果评价

Clinical effect of transcutanclus electrical acupoint stimulation for patients with non-small cell lung cancer during chemotherapy

目的观察经皮穴位电刺激预防非小细胞肺癌(NSCLC)患者化疗期间骨髓抑制的临床效果。方法 86例NSCLC患者按照随机数字表法分为观察组和对照组,各43例,均行吉西他滨联合顺铂化疗并予以常规护理。观察组加用经皮穴位电刺激并实施针对性护理干预。比较2组化疗期间骨髓抑制发生情况、血常规变化,评价患者舒适度。结果观察组化疗期间白细胞抑制、粒细胞抑制发生率显著低于对照组(P<0.05);2组患者化疗后白细胞、血小板水平均降低,且对照组降低更为显著,差异有统计学意义(P<0.05);与化疗前比较,对照组化疗后第3天和第6天后的舒适评分降低(P<0.05),观察组舒适评分变化差异无统计学意义(P>0.05)。结论经皮穴位电刺激能有效降低NSCLC患者化疗期间骨髓抑制发生风险,改善舒适度。

Objective To observe the clinical effect of transcutanclus electrical acupoint stimulation to reduce the bone marrow suppression of patients with non-small cell lung cancer （NSCLC） during chemotherapy. Methods A total of 86 NSCLC patients were assigned to the obser- vation group （ n = 43） and the control group （ u = 43 ） in accordance with the random number table. Both two groups received chemotherapy with gemcitabine and cispIatin and conventional nursing care. The observation group was given transcutanclus electrical acupoint stimulation and related nursing in- tervention additionally. The incidence of bone marrow suppression and changes in blood tests indicators were observed, and the degree of comfort to nursing service was evaluated. Results The incidence of leukocyte and granulocyte were lower in the observation group than those in the control group during chemotherapy（P 〈0.05 ） . Levels of leucocyte and platelet were decreased in both of two groups after chemotherapy, and were lower in the control group than those in the observation group （ P 〈 0.05 ）. The score of comfort assessment was decreased in the control group at 3 and 6 days after initiation of chemotherapy compared with that before chemotherapy （P 〈 0.05 ） , but with no significant difference in the observation group （ P 〉 0.05 ）. Conclusion Transcutanclus electrical acupoint stimulation could reduce the risk of bone marrow suppression and increase the degree of comfort in NSCLC patients during chemotherapy.