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呼吸系统雾化基因治疗研究进展 被引量：2

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摘要 基因治疗作为新的分子治疗手段对人类疾病的治疗有重大影响，然而基因治疗的安全性和有效性是其应用于临床治疗的主要障碍。呼吸系统的结构特点和生理功能使其内表面与外界环境充分接触，这样以雾化形式进行基因治疗为呼吸道疾病治疗提供了一种新的手段。
作者 孙文武 马壮
机构地区 沈阳军区总医院呼吸内科
出处 《中华肺部疾病杂志（电子版）》 CAS 2016年第5期554-557,共4页 Chinese Journal of Lung Diseases(Electronic Edition)
基金 军队"十五"基金资助课题(01MB001)
关键词 呼吸系统疾病 雾化治疗 基因治疗
分类号 R563 [医药卫生—呼吸系统]
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参考文献50

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  • 2Bragonzi A, Dina G, Villa A, et al. Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs [J]. Gene Ther, 2000, 7(20): 1753-1760.
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二级参考文献25

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  • 4Lentz Y K, Anchordoquy T J, Lengsfeld C S. Rationale for the selection of an aerosol delivery system for gene delivery. J Aerosol Medicine, 2006, 19:372-384.
  • 5Davies L A, Hannavy K, Davies N, et al. Eleetrohydrodynamic comminution: A novel technique for the aerosolisation of plasmid DNA. Pharm Res, 2005, 22:1294-1304.
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中华肺部疾病杂志（电子版）
2016年 第5期

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