流式细胞术诊断多发性骨髓瘤的研究进展

Research Progress on Role of Flow Cytometry in Diagnosis of Multiple Myeloma——Review

多发性骨髓瘤(multiple myeloma,MM)是B细胞的恶性肿瘤,居血液系统恶性肿瘤第二位,预后不良。骨髓中异常浆细胞数量以及血液或尿中单克隆蛋白为其主要诊断标准,但存在着局限性。多参数流式细胞术的免疫学分析越来越多地被使用到MM的诊断中,本文主要从恶性浆细胞和骨髓瘤祖细胞的免疫表型特征作一综述。

Multiple myeloma（MM）,the second common malignant tumor in the blood system,is a kind of B cell malignancy and its prognosis is poor.The diagnosis of MM is mainly based on the number of abnormal plasma cells and the presence of monoclonal protein in the blood or urine,but there are limitations for diagnosis of MM.Multi-parameter flow cytometry analysis is increasingly used in the in the diagnosis of MM.Therefore,this review focuses on characteristics of immunophenotypes of malignant plasma cells and myeloma progenitor cells.