外周血指标对急性出血性脑卒中深静脉血栓的诊断价值研究

Diagnostic value of peripheral blood indexes for deep venous thrombosis after acute hemorrhagic stroke

目的探讨P选择素、D-二聚体、同型半胱氨酸(Hcy)超敏C反应蛋白(hs-CRP)对急性出血性脑卒中的诊断价值。方法于2015年3月至2016年3月,根据血栓形成情况,将60例急性出血性脑卒中患者分为血栓组(28例)和非血栓组(32例)。20例体检健康纳入对照组。检测各研究组外周血P选择素、D-二聚体、Hcy、hs-CRP水平。结果血栓组患者年龄大于无血栓组(P<0.05)。血栓组P选择素、D-二聚体水平高于无血栓组和对照组(P<0.05);无血栓组P选择素、D-二聚体水平高于对照组(P<0.05)。血栓组、无血栓组hs-CRP水平高于对照组(P<0.05),但血栓组和无血栓组比较差异无统计学意义(P>0.05)。P选择素、D-二聚体联合检测对DVT的诊断灵敏度和特异度分别为96.4%和83.3%,受试者工作特征曲线下面积为0.937。结论 P选择素和D-二聚体联合检测对脑卒中后DVT具有较高的诊断价值。

Objective To explore the diagnostic value of P-selectin,D-Dimer,homocysteine（Hcy）,high-sensitive C-reaction protein（hs-CRP）for deep venous thrombosis（DVT）after acute hemorrhagic stroke.Methods From Mar.2015 to Mar.2016,60 patients with acute hemorrhagic stroke were divided into thrombus group（28cases）and non-thrombus group（32cases）,and 20 healthy subjects were enrolled as control group.Levels of P-selectin,D-Dimer,Hcy and hs-CRP were detected.Results Age of patients in thrombus group was higher than non-thrombus group（P〈0.05）.Levels of P-selection and D-Dimer of thrombus group were higher than non-thrombus group and control group（P〈0.05）,and those of non-thrombus group were higher than control group（P〈0.05）.Levels of CRP of thrombus group and non-thrombus group were higher than control group（P〈0.05）,but there was no significant difference between non-thrombus group and control gorup（P〉0.05）.The diagnostic sensitivity and specificity of combined detection of P-selection and D-Dimer to DVT were 96.4% and 83.3%,the area under receiver operating characteristic curve was 0.937.Conclusion Combined detection of P-selection and D-Dimer could be with high diagnostic value for DVT after acute hemorrhagic stroke.