冠心病患者血清补体C1q水平变化及其临床意义

Changes and clinical significance of serum complement C1q level in patients with coronary heart disease

目的探讨冠状动脉粥样硬化性心脏病(CHD)患者血清补体C1q水平变化及其临床意义。方法于2015年10月至2016年3月,选择住院治疗CHD患者92例,根据临床类型分为稳定性心绞痛(SAP)组和急性冠脉综合征(ACS)组。以同期体检健康者50例作为对照组。检测各组受试者血清C1q水平。结果 ACS组血清C1q水平高于对照组和SAP组(P<0.05),SAP组与对照组C1q水平比较差异无统计学意义(P>0.05)。结论 CHD患者血清C1q水平变化与病情进展相关,检测血清C1q有助于判断患者病情及指导临床治疗。

Objective To study the changes and clinical significance of serum complement C1 q level in patients with coronary heart disease（CHD）.Methods From Oct.2015 to Mar.2016,92 CHD patients were enrolled,and divided into stable angina pectoris（SAP）group and acute coronary syndrome（ACS）group according to the clinical condition.Another 50 healthy subjects were enrolled as control group.Serum concentrations of C1 q were measured in all groups.Results Serum concentrations of C1 q in ACS group was higher than control group and SAP group（P〈0.05）.There was not significantly difference of serum concentrations of C1 q between SAP group and control group（P〉0.05）.Conclusion Serum C1 q level could be associate with the progression of CHD disease,and detection of serum C1 q might be helpful for judging patients′condition and guiding treatment.