摘要
利用1-氰-2,2-二苯环丙烷与乙二胺对甲苯磺酸合成了2-(2,2-二苯基环丙基)-4,5-二氢-1H-咪唑。重点考察了反应温度、反应时间、冷却温度等影响因素来讨论合成工艺的研究。实验结果表明:反应体系升温至205℃,反应80 min,反应完毕后,降温至70℃左右,2-(2,2-二苯基环丙基)-4,5-二氢-1H-咪唑收率可达到96.9%。该方法操作简单,原料及试剂来源方便,反应过程毒性小,目标产物收率较高,适合工业化生产。
2-chloroquinoline-3-carbaldehyde was synthesized by the reaction of 1-cyano-2,2-diphenylcyclopropane and ethylene diamine monotosylate was synthesized. The reaction temperature,reaction time and the cooling temperature were inspected. The results of test showed that reaction system heated up to 205 ℃ for 80 min,after the completion of reaction,cooled to about 70 ℃. The yield of 2-( 2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole was 96. 9%. The method has the advantages of simple operation,convenient source of raw materials and reagents,small toxicity reaction process,cost-effective and the high yield,which is suitable for industrialized production.
出处
《广州化工》
CAS
2016年第20期59-60,63,共3页
GuangZhou Chemical Industry