肿瘤标志物蛋白芯片用于肿瘤筛查的实用性研究

Application of multi-tumor marker protein chip for tumor screening

目的探讨肿瘤标志物蛋白芯片(C12)快速检测系统进行肿瘤早期筛查及诊断的实用性。方法应用C12检侧系统,对2011年11月至2015年12月在奉城医院健康体检人群和临床检验标本中涉及高危人群的血清10 736例,进行12种常见肿瘤标志物(AFP、CEA、CA125、CA15-3、CA19-9、CA242、NSE、fPSA、PSA、β-HCG、HGH、Ferritin)定量检测,并对结果进行统计分析。结果 10 736例标本中共检出阳性967例,其中男496例,阳性检出率4.62%(496/10 736);女471例,阳性检出率4.39%(471/10 736);967例阳性标本经临床病理学确诊为肿瘤患者473例,阳性诊断率48.91%(473/967)。结论 C12检测系统联合检测多种肿瘤标志物,减少了多项目分别单一检测的繁琐流程,达到快速检测多项指标的目的,对提高肿瘤的检出率及恶性肿瘤的早期快速筛查具有一定的临床价值。

Objective To study the application of multi-tumor marker protein chip for early tumor screening and diagnosis.Methods From Nov.2011 to Dec.2015,10 736 samples,including people receiving physical examination and with high risk of cancer in Fengcheng Hospital were collected.Twelve tumor markers in serum（AFP,CEA,NSE,CA125,CA153,CA242,CA199,PSA,fPSA,FER,β-HCG and HGH）were measured by multi-tumor markers protein chip detective system,and the results were analyzed.Results We found out 967 samples with positive markers in the 10 736 samples.Of which,496 were male and 471 were female,the positive rate were 4.62% and 4.39%respectively.Totally 473 were diagnosed with tumor confirming by clinical pathology,postive diagnosis rate was 48.91%.Conclusion The multi-tumor marker protein chip（C12system）can detect multiple tumor markers simultaneously to improve screening process and achieve rapid detection,which has higher positive detectiong rate and clinical value on diagnosing malignant tumor in early stage.