注射用丹参多酚酸盐治疗慢性肾衰竭疗效分析

目的:观察注射用丹参多酚酸盐治疗慢性肾衰竭中的疗效。方法:64例随机数字表法分为对照组和观察组各32例。两组均采用常规口服药物治疗,观察组加用丹参多酚酸盐注射治疗,治疗2周后比较两组肾功能。结果:两组尿素氮、血肌酐均较本组治疗前下降(P<0.05),内生肌酐清除率较前明显升高(P<0.05),治疗后观察组尿素氮、血肌酐水平明显低于对照组(P<0.05),内生肌酐清除率明显高于对照组(P<0.05)。结论:注射用丹参多酚酸盐可以保护肾功能,延缓慢性肾衰竭的进展。

Objective ： To observe the clinical effect of Salvianolate Injection in the treatment of chronic renal failure. Method： 64 cases with chronic renal failure were randomly divided into control group （ n=32 ） and observation group （ n=32 ） . Both groups were treated with conventional oral drugs and the observation group were treated with Salvianolate Injection additionally. After two weeks treatment, renal function between the two groups of patients was compared. Result： After two weeks of treatment, the urea nitrogen, serum creatinine of the two groups were both decreased compared with that before treatment and endogenous creatinine clearance rate was significantly higher than before. The level of urea nitrogen, serum creatinine of the observation group after the treatment was obviously lower than that of the control group while the endogenous creatinine clearance of the observation group after the treatment was significantly higher than that of the control group. The difference was statistically significant （ P〈0.05 ） .Conclusion： Salvianolate Injection could protect renal function and delay the progression of chronic renal failure.