不同类型HPV与宫颈上皮内瘤变和宫颈癌的关系

Relationship between different HPV types, cervical intraepithelial neoplasias and cervical cancer

目的探讨不同类型人乳头状瘤病毒（HPV）与宫颈上皮内瘤变（CIN）及宫颈癌的关系。方法 80例CIN患者及30例宫颈癌患者,应用第二代杂交捕获试验法（HCⅡ）对HPV进行检测,分析不同类型HPV与宫颈上皮内瘤变和宫颈癌的关系。结果 CINⅠ级患者于20~35岁年龄段占比最高（66.7%）;CINⅡ~Ⅲ级患者于20~35岁年龄段占比最高（47.7%）;宫颈癌患者于35~50岁年龄段占比最高（30.0%）。〈20岁、20~35岁、35~50岁、50~65岁HPV阳性患者均以HPV6/11分型占比最高,〉65岁HPV阳性患者以HPV18分型占比最高。CINⅠ级患者中以低危型HPV6/11分型占比最高,CINⅡ~Ⅲ级患者中以高危型HPV16分型占比最高,宫颈癌患者中以高危型HPV18分型占比最高。结论 HPV感染率与宫颈病变程度高低成正相关关系,且HPV分型在不同宫颈病变中存在不同差异。

Objective To investigate relationship between different human papilloma virus（HPV） types, cervical intraepithelial neoplasias（CIN） and cervical cancer. Methods A total of 80 CIN patients and 30 cervical cancer patients received hybrid capture test Ⅱ（HCⅡ） for HPV detection. Analysis was made on relationship between different HPV types, cervical intraepithelial neoplasias and cervical cancer. Results Patients aging 20~35 years old showed the highest proportion in grade Ⅰ CIN cases（66.7%）; patients aging 20~35 years old showed the highest proportion in grade Ⅱ~Ⅲ CIN cases（47.7%）; cervical cancer cases had the highest proportion as 30.0% in patients aging 35~50 years old. HPV6/11 showed the highest proportion in HPV positive patients aging〈 20 years old, 20~35 years old, 35~50 years old and 50~65 years old. Patients aging 〉65 years old had the highest proportion of HPV18. Low risk HPV6/11 accounted for the highest proportion in grade Ⅰ CIN cases, high risk HPV16 accounted for the highest proportion in grade Ⅱ~Ⅲ CIN cases, and high rish HPV18 accounted for the highest proportion in cervical cancer cases. Conclusion HPV infection rate is positively correlated with degree of cervical lesions, and HPV types differ in various cervical lesions.