探讨阿莫西林与阿莫西林双氯西林钠对幽门螺杆菌根治的疗效观察

Investigation of curative effects observation by amoxicillin and amoxicillin and dicloxacillin sodium in radical treatment of helicobacter pylori

目的研究分析幽门螺杆菌(Hp)使用阿莫西林三联疗法与阿莫西林双氯西林钠三联疗法根治的效果。方法 300例Hp阳性消化性溃疡患者,随机分为A、B两组,各150例。A组给予阿莫西林三联疗法,B组给予阿莫西林双氯西林钠三联疗法。比较两组的治疗效果。结果 A组痊愈率72.0%、Hp根除率76.7%低于B组91.3%、96.0%(P<0.05)。A组不良反应几率1.3%与B组2.0%比较差异无统计学意义(P>0.05)。结论阿莫西林双氯西林钠治疗消化性溃疡的效果优于单纯阿莫西林治疗,值得推广使用。

Objective To research and analyze effects by amoxicillin triple therapy and amoxicillin and dicloxacillin sodium triple therapy in radical treatment of helicobacter pylori（Hp）. Methods A total of 300 peptic ulcer patients with positive Hp were randomly divided into group A and group B, with 150 cases in each group. Group A received amoxicillin triple therapy, and group B received amoxicillin and dicloxacillin sodium triple therapy. Their curative effects were compared. Results Group A had lower cure rate as 72.0% and Hp eradication rate as 76.7% than 91.3% and 96.0% in group B（P〈0.05）. There was no statistically significant difference of incidence of adverse reactions between 1.3% in group A and 2.0% in group B（P〉0.05）. Conclusion Amoxicillin and dicloxacillin sodium provides better effect in treating peptic ulcer than amoxicillin alone, and it is worth promoting and applying.