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转录辅助因子PC4在肿瘤中的研究进展

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摘要 转录辅助因子PC4（Transcriptional positive coactivator 4）,是一个功能强大的辅助激活因子,不仅参与转录,还参与DNA复制、损伤修复,染色质形成和细胞周期调控。近年来,通过PC4在肺癌、食管鳞癌、星型细胞瘤等肿瘤中的研究发现,PC4与肿瘤关系密切。它参与肿瘤发生发展及转移过程,并且与肿瘤治疗、预后密切相关。本文就PC4结构和功能、参与p53正反馈调控、参与肿瘤发生发展的研究作简要综述。
作者 谢加琼 任黔川
机构地区 西南医科大学附属医院妇产科
出处 《泸州医学院学报》 2016年第5期491-494,共4页 Journal of Luzhou Medical College
关键词 转录辅助因子PC4 肿瘤 研究进展
分类号 R73 [医药卫生—肿瘤]
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参考文献32

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泸州医学院学报
2016年 第5期

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