衰老相关分泌表型的研究进展

The research progress of senescence-associated secretory phenotype

细胞衰老的同时常伴随着衰老相关分泌表型(senescence-associated secretory phenotype,SASP)的产生。SASP由促炎细胞因子、生长因子、趋化因子和基质重塑酶等一系列细胞因子组成,它们可以导致机体慢性低度炎症和疾病,并可以反作用于衰老细胞及其邻近细胞加速它们的衰老进程,并可作为新的细胞衰老效应机制。该文通过对SASP生物学功效、分泌调节、机制、以及与相关疾病关联的探讨,提高我们对SASP的认知,引发我们对SASP相关疾病疗法的思考。

When senescence induction is based on DNA damage,senescent cells display a unique phenotype,which has been termed 'senescence-associated secretory phenotype '( SASP).SASP, including proinflammatory cytokines, growth factors,chemokines,matrix remodeling enzymes and other cytokines,may be an important driver of chronic inflammation and therefore may be part of a vicious cycle of inflammation,DNA damage and senescence. Senescence-associated secretory products released by such cells can affect the neighboring cells and further exacerbate their regenerative capacity. SASP is associated with many chronic age-related diseases.