奥美拉唑对幽门螺杆菌引起的胃溃疡患者临床疗效分析

Clinical efficacy analysis on omeprazole in patients with stomach ulcers caused by Helicobacter pylori

目的 分析奥美拉唑对幽门螺杆菌引起的胃溃疡患者的治疗效果.方法 选取2015 年3 月～ 2016 年5 月收治的106 例幽门螺杆菌引起的胃溃疡患者作为研究对象,按随机数字表法分为观察组（53 例）、对照组（53 例）.观察组患者应用奥美拉唑进行治疗,对照组患者应用西咪替丁进行治疗.对比两组患者经不同方式治疗后的相关观察指标变化情况及其效果.结果 经不同方式治疗后,观察组患者的胃泌素水平（90.08±8.70）μmol/L 较对照组患者的胃泌素水平（105.40±9.40）μmol/L 明显降低;观察组患者的胃液pH 值（6.80±1.00）、胃动素水平（229.00±18.50）ng/L 以及治疗总有效率（98.11%）和对照组的胃液pH 值（3.10±0.81）、胃动素水平（202.27±18.47）ng/L 以及治疗总有效率（86.79%）比较明显升高,差异有统计学意义（P 〈 0.05）.结论 在幽门螺杆菌引起的胃溃疡的治疗过程中,奥美拉唑能够显著改善胃泌素、胃动素等相关指标,提高临床疗效.

Objective To analyze the effects of omeprazole treatment in patients with gastric ulcer caused by Helicobacter pylori. Methods One hundredand six patients with gastric ulcer caused by Helicobacter pylori in our hospital between March 2015 and May 2016 were randomly divided into two groups,observation group and control group. Fifty-three patients in the observation group were given omeprazole, while 53 patients in the control group were treatedwith cimetidine. Different observation indicators and outcome after different treatments in two groups were compared. Results After different treatments,gastrin levels in the observation group（ 90.08 ±8.70） μmol/L were obviously lower than that in the control group（ 105.40±9.40） μmol/L; gastric pH value（6.80±1.00）, motilin levels（ 229.00±18.50） ng/L and the total effective rate（ 98.11%） in the observation group were obviously higher than that in thecontrol group（ 3.10±0.81）,（ 202.27±18.47） ng/L,（ 86.79%）, the difference was statistically significant（ P 〈 0.05）. Conclusion In the treatment ofHelicobacter pylori-induced gastric ulcer, omeprazole can significantly improve gastrin, motilin and other related indicators, and improve clinical outcomes.