阿奇霉素在儿科临床应用的不良反应与药学分析

Analysis of adverse reactions of azithromycin in pediatric clinical application and pharmaceutical

目的 观察阿奇霉素在儿科临床应用中的不良反应及其药学分析情况.方法 选取2013 年5 月～ 2015 年6 月收治的47 例患儿,根据数字随机分配的原则,将患儿分为观察组（24 例）与对照组（23 例）,对照组患儿给予静脉滴注阿奇霉素,观察组患儿给予口服阿奇霉素,对比观察两组患儿不良反应发生情况.结果 全部患儿均顺利完成本次治疗,观察组患儿发生不良反应10 例（10/24,41.7%）,对照组19 例（19/23,82.6%）,两组患儿不良反应发生率比较,差异有统计学意义（P 〈 0.05）.患儿停药后,不良反应均自行消失.结论 阿奇霉素可引起患儿出现各种不良反应,严重影响患儿的治疗效果.应加强适应证观察,口服阿奇霉素的安全性比注射用阿奇霉素更高,因此临床应用阿奇霉素治疗过程中,应遵循“能口服不肌注,能肌注不输液”原则,增加用药的安全性.

Objective To observe the adverse reactions of azithromycin in pediatric clinical application and analysis its pharmaceutical application.Methods 47 cases of children treated in hospital from June 2013 to May 2015 were selected. According to the principle of random distribution, they weredivided into observation group of 24 cases and control group of 23 cases. Children in the control group were given intravenous infusion of azithromycin,the observation group were given oral azithromycin, and the adverse reactions of the two groups were compared. Results All the patients were successfullycompleted the treatment, and the incidence of adverse reactions in the two groups were compared. The results were significantly different（P 〈 0.05）. Afterstopping the drug, the adverse reactions were all self disappeared. Conclusion Azithromycin can cause a variety of adverse reactions in children, seriouslyaffect the treatment effect of children. From the point of view of medication, we should strengthen the indications. The safety of oral azithromycin was higherthan the injection.