摘要
目的寻找新型、高效的5-氟尿嘧啶(5-Fu)前药并测定其抗肿瘤活性。方法在5-氟尿嘧啶的N1和N3位引入具有抗肿瘤活性的取代基,合成其前体药物,利用MTT方法测定其对不同肿瘤细胞的增殖抑制活性。结果合成的6个5-氟尿嘧啶前体药物均显示了较好的肿瘤细胞增殖抑制活性。结论新型5-氟尿嘧啶前药对肿瘤细胞有较好的抑制活性,值得进一步研究。
Objective To synthesize and evaluate novel and potent prodrugs of 5-fluorouracil（5-Fu）.Methods Six prodrugs of 5-Fu were prepared by incorporated various substituents on N^1 and N^3 position.The in vitro antiproliferative activity against five cancer cell lines was evaluated by MTT assay.Results All the six prodrugs of 5-Fu displayed potent antiproliferative activity against cancer cell lines.Conclusion These novel prodrugs exhibited potent anticancer activity,and were worth of further investigation.
出处
《西北药学杂志》
CAS
2016年第6期613-615,共3页
Northwest Pharmaceutical Journal
基金
陕西省社会发展攻关项目(编号:2013K14-02-08)
