不同剂量米非司酮治疗子宫肌瘤的疗效分析

Efficacy of different doses of mifepristone in the treatment of uterine fibroids

目的探讨不同剂量米非司酮治疗子宫肌瘤的疗效。方法选取2014年4月至2015年4月间三亚市中医院收治的96例子宫肌瘤患者,采用随机数字表法将患者随机分为大剂量组和小剂量组,每组48例。大剂量组患者采用口服25 mg米非司酮,每天1次。小剂量组患者采用口报12.5 mg米非司酮,每天1次。比较两组患者的疗效。结果两组患者治疗后总有效率的差异无统计学意义(P>0.05)。大剂量组患者药物不良反应显著高于小剂量组,差异有统计学意义(P<0.05)。小剂量组患者治疗后,卵泡生成激素(FSH)、黄体生成激素(LH)、雌二醇(E2)和孕酮(P)水平显著低于大剂量组,差异有统计学意义(P<0.05)。小剂量组患者治疗后行经期和月经量显著高于大剂量组,差异有统计学意义(P<0.05)。结论口服12.5 mg米非司酮,每天1次,是治疗子宫肌瘤安全、有效的剂量。

Objective To explore the efficacy of different doses of mifepristone in the treatment of uterine fibroids. Methods 96 patients with uterine fibroids treated in Sanya Traditional Chinese Medicine Hospital from April 2014 to April 2015 were selected. Using random number table,the patients were divided into the high-dose group and small-dose group,with 48 patients in each group. Patients in high-dose group received 25 mg mifepristone once daily,while patients in small-dose group received 12. 5 mg mifepristone once daily. The efficacy was compared between the two groups. Results The total effective rate has no statistical significance between the two groups（ P〉 0. 05）. Patients in high-dose group had a significantly higher incidence of adverse drug reactions than that in low-dose group（ P〈 0. 05）. Levels of folliclestimulating hormone（ FSH）,luteinising hormone（ LH）,estradiol（ E2）,progesterone（ P） in small-dose group after treatment was significantly lower than those of high-dose group（ P〈 0. 05）. After treatment,menstruation and menstrual volume in small dose group was significantly higher than that in high dose group（ P〈 0. 05）. Conclusion 12. 5 mg mifepristone once daily is a safe and effective for uterine fibroids.