利福喷丁抗结核治疗进展

Progress of rifapentine in the treatment of tuberculosis

利福喷丁是抗结核治疗的重要药物，作者回顾了利福喷丁的药理特点、近年来利福喷丁在潜伏性结核感染及活动性结核病患者中的应用、不良反应的发生情况，肯定了利福喷丁抗结核病的疗效。进而指出，目前利福喷丁的研究热点是吸入制剂的研发，在特殊人群结核病及其他疾病方面的应用，以及利福喷丁的使用剂量与血浆药物浓度、疗效之间的关系，这些研究有望更好地发挥该药抗结核病的作用。

Rifapentine is important in the treatment of tuberculosis. The pharmacological mechanism anct the recent use of rifapentine in the treatment of LTBI and active tuberculosis, as well as its reverse d{ects were reviewed in this article. The analysis showed that rifapentine is effective in the treatment of LTBI and active tuberculosis. Recent researches focus on the inhale form of rifapentine, and the use of rifapentine in some special patients and other diseases, and the relationship between dosage and parmacokineetics and efficacy, and these researches are expected to help rifapentine playing better role in clinical protocols.