胸腺五肽联合头孢曲松钠治疗早期梅毒血清固定患者的疗效及护理

Efficacy and clinical nursing of thymopentin combined with ceftriaxone on patients with early syphilis serum fixation

目的：探讨胸腺五肽联合头孢曲松钠配合临床护理措施治疗早期梅毒血清固定患者的临床效果。方法选取早期梅毒血清固定患者108例为研究对象，按照数字表法分为观察组及对照组，每组各54例。其中对照组患者行常规青霉素钠联合苄星青霉素配合护理措施治疗，观察组患者行胸腺五肽联合头孢曲松钠配合护理措施治疗，对比观察两组患者治疗前后各项相关指标变化情况。结果治疗后，观察组IL-2、IL-10等免疫功能指标改善情况明显优于对照组[IL-2：对照组治疗前（20．8±4．9）μg／L、治疗后（42．7±7．3）μg／L；观察组治疗前（19．8±5．1）μg／L、治疗后（54．6±8．3）μg／L；IL-10：对照组治疗前（76．3±16．1）μg／L、治疗后（51．3±5．4）μg／L；观察组治疗前（78．3±4．1）μg／L、治疗后（23．8±5．1）μg／L]，两组治疗后差异均有统计学意义（t ＝3．923、8．832，均 P ＜0．05）；治疗后，观察组3、6、12个月时 RPR 转阴率明显高于对照组，观察组72．2％、85．2％、96．3％；对照组53．7％、57．4％、63．0％，差异均有统计学意义（χ^2＝4．932、11．372、22．842，均 P ＜0．05）；观察组治疗后3、6、12个月时疗效明显优于对照组，观察组有效率分别为75．9％、79．6％、75．9％；对照组有效率分别为72．2％、64．8％、57．4％，两组治疗后6、12个月有效率差异均有统计学意义（χ^2＝5．232、6．183，均 P ＜0．05）。结论联合胸腺五肽及头孢曲松钠治疗早期梅毒血清固定可明显改善其免疫学指标，配合护理措施加强患者防范意识，效果较好，值得于临床中进一步推广使用。

Objective To evaluate efficacy of thymopentin combined with ceftriaxone on patients with early syphilis serum fixation.Methods A total of 108 patients with early syphilis serum fixation were chosen and divided into observation group and control group by the number of tables （54 cases in each group）.The control group were underwent conventional sodium penicillin with benzathine with nursing treatment,the observation group were treated with ceftriaxone thymopentin combined with nursing treatment,changes in the relevant indicators before and after treat-ment were observed.Results After treatment,IL -2,IL -10 and other indicators in the observation group were improved compared to the control group[IL -2：the control group before treatment （20.8 ±4.9）μg/L,after treatment （42.7 ±7.3）μg/L;the observation group before treatment（19.8 ±5.1）μg/L,after treatment （54.6 ±8.3）μg/L;IL -10：the control group before treatment （76.3 ±16.1）μg/L,after treatment （51.3 ±5.4）μg/L;the observation group before treatment（78.3 ±4.1）μg/L,after treatment（23.8 ±5.1）μg/L],the differences of the two groups after treatment were statistically significant （t =3.923,8.832,all P 〈0.05）;after treatment,the RPR negative rates of the observation group at 3,6,12 months after treatment（72.2%,85.2%,96.3%）was significantly higher than those of the control group（53.7%,57.4%,63.0%）,the differences were statistically significant （χ^2 =4.932,11.372, 22.842,all P 〈0.05）;the efficacy of the observation group at 3,6,12 months after treatment（75.9%,79.6%, 75.9%）were significantly better than those of the control group （72.2%,64.8%,57.4%）,the differences were statistically significant （χ^2 =5.232,6.183,all P 〈0.05 ）.Conclusion Thymopentin combined with ceftriaxone treatment of early syphilis can significantly improve its fixed immunological parameters,which coordinated with nursing measures can strengthen patient care awareness,then the efficacy will be better,so it is worthy of clinical furtherpromotion.